http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19801319-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aeb5756b7052873e9c99188f25262de1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
| filingDate | 1998-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0552a18c6a74784691b7e0445ab272df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82f9e5982bb86081e4212587e5cd8cf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2e4c63f2762e5430b99ee443d305be5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a8cf83efd7fbf3a874a28cad4156ace http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57ae4f3d85aa33ce1f0d9d77b98755f1 |
| publicationDate | 1999-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-19801319-A1 |
| titleOfInvention | Receptor binding assays for the detection of TSH receptor autoantibodies as well as reagents and reagent kit for performing such a receptor binding assay |
| abstract | Determining the presence of auto-antibodies (AAb) to thyroid stimulating hormone (TSH) receptor (TSHR) in a biological sample, using a receptor binding assay, is characterized by the use of a functional recombinant TSHR (rTSHR) as TSHR composition. Determining the presence of auto-antibodies (AAb) to thyroid stimulating hormone (TSH) receptor (TSHR) in a biological sample, using a receptor binding assay, is characterized by the use of a functional recombinant TSHR (rTSHR) as TSHR composition. Recombinant TSHR is bound via a selective antibody (anti-TSHR-Ab) to TSHR to a solid phase. The bound rTSHR is purified by washing and then transferred to an affinity-purified immobilized rTSHR (rTSHR(imm)). The biological sample is reacted with: (i) a TSHR composition and (ii) a labeled bovine TSH (bTSH). The presence of Aab is determined by the amount of bound, labeled bTSH in from the fluid phase-separated complex from bTSH, especially TSHR-Aab with TSHR. Independent claims are also included for : (1) a reagent kit comprising the ingredients described above; and (2) the use of a low-molecular fraction of human serum or its derivatives, two-valent metal ions and/or sulfate group comprising polysaccharides, for increasing the binding of TSH to a TSHR in a receptor binding assay. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004108762-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10035706-C2 |
| priorityDate | 1998-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 223.