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filingDate 1969-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8baa87b5e33f910f17c5d7d93185d43e
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publicationDate 1970-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-1965894-A1
titleOfInvention New 2-hydrazine benzodiazepine derivatives and processes for their preparation
abstract Benzodiazepines of formula (I) and the 5-N-oxides (where R1 = H or a hydrocarbon residue, e.g. (1-6C) alkyl, (7-8C) aralkyl or aryl, R2 = H or alkyl, and rings A and/or B may be substd. by one or more NO2, CF3, hal., alkyl or alkoxy), are of use as muscle relaxants, anticonvulsants, sedatives and tranquillisers, at a dose of 1-30 mg./d. (p.o.), or 0.5-10 mg/d. (parenteral). (I) are prepd. by reaction of the novel hydrazides (II) with a carboxylic acid R'CO2H (III) or its reaction deriv. Sedative chloro-phenyl-triazolobenzodiazepines.. followed by ring closure if necessary. The reaction is carried out with 1-10 mol. (III) at 0-300 degrees in the presence of an acid catalyst. (II) are prepd. from the corresp. amine, alkylthio or aralkylthio deriv. and N2H4.
priorityDate 1969-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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