http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19631541-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J13-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 |
| filingDate | 1996-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_872ef2cbe45c185984f7c52ec9e5c6ad |
| publicationDate | 1997-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-19631541-C1 |
| titleOfInvention | Process for the preparation of 16alpha-hydroxy-estra-1,3,5 (10) -triene derivatives |
| abstract | A process is disclosed for preparing 16 alpha -hydroxy-estra-1,3,5(10)-triene derivatives having the general formula (I), in which R1 stands for a hydrogen atom, an alkyl group with maximum 4 carbon atoms, a benzyl group or an acyl group with maximum 8 carbon atoms; and X and Y represent together an oxo group or X stands for a hydroxyl group and Y for a hydrogen atom. This process is characterised in that an estra-1,3,5(10),16-tetraene derivative is converted by means of peracids into a 16 alpha ,17 alpha -epoxide, which is split by means of mineral acids or converted by means of a reagent which supplies bromine cations into the corresponding 16 alpha -bromine derivative, which is converted into the 16 beta -bromine derivative. The bromine is replaced by an hydroxyl group and if required the thus obtained 16 alpha -hydroxy-1,3,5(10)triene-17-one derivative is reduced by means of sodium hydroboron in the presence of a strong aqueous buffer solution with a pH value from 5 to 6.5 into the corresponding 16 alpha ,17 beta -trihydroxy-estra-1,3,5(10)-triene derivative. |
| priorityDate | 1996-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.