abstract |
The present invention relates to the novel 7 alpha -(5-methylaminopentyl)-estratrienes of the general formula (I), in which R<2> is a hydrogen or fluorine atom, R<17> is a hydrogen atom, a methyl or ethynyl group, n is 2, 3 or 4, and x is 0, 1 or 2. The novel compounds are strong, pure anti-estrogenes and can be used to produce drugs to treat oestrogene-dependent diseases, for example, breast cancer, endometrial cancer, prostate hyperplasia, anovular infertility and melanoma. |