http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19605024-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 |
| filingDate | 1996-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecf259c63ecd601aee8c3f5a563cac62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0013552a1230a8354222007a67a7f65a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a5547c752624f4a69285d1365ae7cb6 |
| publicationDate | 1997-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-19605024-A1 |
| titleOfInvention | New selective taxanes, processes for their preparation and their pharmaceutical use |
| abstract | There are described taxanes of general formula (I), wherein Sk may be (i), R<1> may be hydrogen or C1-C10 acyl, R<2> may be alpha -OH or beta -OH, R<3> may be C1-C10 alkyl, X-substituted phenyl, C1-C10 alkoxy, X may be hydrogen, halogen, -N3 or -CN, and free hydroxy groups in (I) may be functionally modified further by etherification or esterification, and also the alpha -, beta - and gamma -cyclodextrin clathrates thereof, and also compounds of general formula (I) encapsulated with liposomes. The compounds of formula (I) according to the invention, compared with taxol, have an advantageously altered activity profile. In addition to a clearly improved stabilisation of microtubules, the compounds of formula (I) demonstrate an additional influence on the polymerisation of tubulin. |
| priorityDate | 1996-01-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 161.