| abstract |
Process for preparing a non-solvated crystalline 6-hydroxy-2- (4-hydroxyphenyl) -3- [4- (2-piperidinoethoxy) benzoyl] - benzo [b] thiophene hydrochloride having a defined X-ray diffraction spectrum, by acylating a benzothiophene corresponding to the benzothiophene portion of the compound to be prepared with an acylating agent which provides the remaining portion of the desired compound, dealkylating the phenolic groups of the resulting acylation product and isolating a crystalline solvate of the resulting compound, Reaction of this solvate in methanol or in a mixture of methanol and water with a base, addition of hydrochloric acid to the methanolic solution and isolation of the desired, unsolvated crystalline compound. After this, for example, a new non-solvated crystalline form of raloxifene hydrochloride can be prepared which is substantially free of chlorobenzene and impurities by aluminum salts and organoaluminum compounds and which is also virtually odorless. |