http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19543865-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
| filingDate | 1995-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952843f006c93e6567c01babbbbcd1af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b7d8102905f07e4023cc7d7a1c51809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74190ca234941567e680c41f0aadeb8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0581e1d7ef125d900ae6de37fcdc83b |
| publicationDate | 1997-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-19543865-A1 |
| titleOfInvention | Phosphonomonoester nucleic acids, process for their preparation and their use |
| abstract | Oligonucleotide analogues and related cpds. of formula (I) are new, in which n = 0-100; B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a label; A = a single bond, CH2, (CR<2>R<3>)pM(CR<2>R<3>)q or (CR<2>R<3>)rM(CR<2>R<3>)sCY'; or A-B = 1-5 D- or L-amino acids condensed on via the carboxyl group; L = N or R<1>N<+>; R<1> = H or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2; Y' = O, S, CH2, CMe2 or NR<1>; M = a single bond, O, S or NR<1>; R<2> and R<3> = H, OH, 1-6C alkoxy, 1-6C alkylthio, NH2, halogen, or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy or 1-6C alkylthio; p, q, r and s = 0-5; D and G = CR<5>R<6>; R<5> and R<6> = H, 1-6C alkyl, 6-20C aryl, (6-20C)aryl(1-6C)alkyl, OH, 1-6C alkoxy or 1-6C alkylthio, where alkyl and aryl are opt. substd. by SR<1> or NR<1>R<1>; X = O, S or NR<1>; Y = O or S; Z = OR<8>, NR<9>R<1 >0 or XQ; R<8> = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl and aryl are opt. substd.; R<9> and R<10> = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl is opt. substd.; or NR<9>R<10> is a 4- to 7-membered ring; Q and Q' = H, R<8>, opt. modified oligonucleotides or conjugates which (a) favourably affect the properties of antisense oligonucleotides, (b) affect the properties of triplex-forming oligonucleotides, (c) serve as DNA probe labels or (d) bind to or crosslink a target nucleic acid during hybridisation; or Q and Q' alone or together are a single bond in a cyclic molecule; or Q and Q', when neither is hydrogen, can be linked together to form a cyclic molecule. |
| priorityDate | 1995-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 573.