| abstract |
Use of a combination of halogenated nitriles of formula Z-(CH2)p-C(X)(Y)-(CHQ)k-CN (I) and alcohols of formula (II) is claimed for the prophylaxis and treatment of the appearance of unclean skin, acne or as an active principle against Gram-positive bacteria, especially Propionibacterium acnes. Q = H or halo; X, Y, Z = H, Q, CN or 1-18C alkyl; p = 0-10; k = 0-18; R1-R5 = H, Me, OMe or NH2; A = H, Me or Et; q, m = 0-10; x, y = 0 or 1; and x may be different when m = 2 or more. |