http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-19508923-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4087 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4006 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 |
filingDate | 1995-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_952843f006c93e6567c01babbbbcd1af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bd0c6b384783b9fa572f05c2893ff80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b7d8102905f07e4023cc7d7a1c51809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0581e1d7ef125d900ae6de37fcdc83b |
publicationDate | 1996-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | DE-19508923-A1 |
titleOfInvention | Phosphonomonoester nucleic acids, process for their preparation and their use |
abstract | Phosphonomonoester oligonucleotide analogues of formula (I) are new, in which n = 0-100; each B = H; OH; or a 1-20C alkyl, alkoxy or alkylthio, 6-20C aryl (opt. as a substit. on 1-6C alkyl, alkoxy or alkylthio), aromatic or heterocyclic gp., each opt. substd. by 1 or more OH, 1-4C alkoxy, NR9R10, COOH, oxo, COOR8, CONR9R10, CN, F, Cl, Br, NO2, 2-6C alkoxyalkyl, S(O)nR8, (1-6C alkyl) S(O)mR8, NHC(=NH)NHR8, C(=NH)NHR8, NR9COR8, NOR8, NR9.COOR10, OCONR9R10 or NR9.CONR9R10; B may also be a natural or unnatural nucleobase or a reporter ligand; or A-B is a D- or L-amino acid (or peptide contg. up to 5 such amino acids) condensed via the COOH; each L = N or R1N<+>; R1 = H or 1-6C alkyl (opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2 (pref. H or Me); each A = single bond, CH2 or a gp. of formula -(CR<2>R<3>)p-M-(CR<2>R<3>)q- or -(CR<2>R<3>)r-M-(CR<2>R<3>)s-C(=Y')- (IIb); Y' = O, S, CH2, CMe2 or NR1<+>; M = single bond, O, S or NR1<+>; R2 and R3 are each H, OH, 1-6C alkoxy or alkylthio, NH2, halo or 1-6C alkyl (opt. substd. by OH or 1-6C alkoxy or alkylthio); p, q, r and s are 0-5; D and G = CR5R6; R5 and R6 = H, 1-6C alkyl (opt. substd. by 6-20C aryl), 6-20C aryl, OH, or 1-6C alkylthio or alkoxy; alkyl and aryl gps. are opt. substd. by SR1 or NR1R'1; R'1 is as R1; X = O, S or NR1<+>; Y = O or S; Z = OR8 or NR9R10; R8 = H; 1-18C alkyl; 2-18C alkenyl; 3-18C alkynyl; 6-12C aryl; 6-12C aryl-(1-6C) alkyl, with alkyl opt. substd. by 1 or more OH, 1-4C alkoxy, F, Cl or Br, and aryl opt. substd. by 1-3 of OH, 1-4C alkyl or alkoxy, F, Cl, Br, NO2, NR9R10, COOH, COO(1-6C alkyl) or CONR9R10 (most esp. H, 1-6C alkyl, phenyl or 2-(4-nitrophenyl)ethyl); R9 and R10 = H, 1-18C alkyl, alkenyl or alkynyl; 6-12C aryl or 6-12C aryl-(1-6C) alkyl, with alkyl opt. substd. by 1 or more OH, 1-4C alkoxy, F, Cl, or Br; or R9 and R10 together complete a 4-7 membered ring; Q and Q' = H; an opt. modified oligonucleotide; or a conjugate that improves the properties of antisense or triplex-forming oligonucleotides, is a marker for a DNA probe, or causes bonding/crosslinking in the hybridisation of (I) to target nucleic acid. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0179216-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0179216-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6777544-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7550582-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0144455-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0144455-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8268560-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6905820-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7241882-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0179249-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0179249-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7897346-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0052038-A1 |
priorityDate | 1995-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 629.