| abstract |
5-Aryl-1H-1,5-benzodiazepin-2,4-diones having sedative and anticonvulsive properties. These compounds have the general formula (in which R, is H, 1-4C alkyl opt. substd. with OH, acyloxy or 2-4C dialkylamino, allyl, cyclohexyl, phenyl opt. substd. with CH3, CH3O or halogen or benzyl, R2 is phenyl opt. substd. with CF3, CN, NO2, halogen or a lower acyl or alkoxycarbonyl group, naphthyl, pyrimidinyl, thienyl or (methyl or halogeno) pyridyl, R3 is H, CF3, CN, halogen, or a 1-2C acyl or alkoxycarbonyl group). Cpds. prepd. by reacting 2-aminodiphenyl- or 2-aminophenyl-heteroaryl-amine with a malonic acid dihalides, and opt. alkylating the product at the 1-position. |