| abstract |
Steroid spirocyclobutanones of formula (I): (in which C5 C6 is a single or double bond; V is H or CH3; one of T and U is =O, the other is 2H. A represents the structures (II), (III), (IV) or (V). (where W is H, an alkyl residue of tetrahydro-pyranyl or acyl; Z is H or methyl residue; and R is H, acyl or alkyl, pref. lower alkyl). Cpds. have pharmacological (e.g. testicular- and prostatic- inhibitory, ovulation inhibitory) activity and are intermediates for spironolactones. |