| abstract |
Compounds (I) and their salts also showing oestrogenic, contraceptive, cardiac and antimycotic action: (where R' and R2 = H, OH, esterified OH, 1-4C alkyl, 1-4 C alkoxy, or PhCH2O, R3 = 1-6C alkyl, X = O or S, Y = H, 1-8C-acyl or together with Z a C-N valency bond providided R3 is not Et when R'=H, R2=MeO, X=S and Y-Z is a bond) are new compounds prepared by (a) cyclising a compound (II) or (III): (where A'=NH2 or Hal, A2= =O, =S, =NH, (NH2) or (H-Hal), at least one of A' and A2 being an N-containing group; B' and B2 are OH or SH or reactive functional derivs. thereof, or one of B' and B2 is H or Hal or (b) reducing or hydrolysing a compound (IV): (where W = OH or Z), and, if desired, appropriately modifying the product esp. by acylation or alkylation. |