| abstract |
Preparation of 4-oxo-19-nor-A-homosteroids (I) and (II):- where R = free or ketalised ketone, free or esterified or etherified hydroxyl in combination with a hydrogen or aliphatic hydrocarbon group or R = hydrogen together with the 1,5-dimethylhexyl-(1)-group R1 = hydrogen or free or esterified hydroxyl group R2 = free or ketalised oxo group, especially the ethylenedioxy group R3 = hydrogen or free or esterified hydroxyl group, or R1, R2 and R3 together represent a bis-methylene-dioxy group. Intermediates. 4-oxo-17-ethylenedioxy-A-homo-DELTA1,5(10)-19-nor-androstadiene is eluted with toluene:ethyl acetate (95:5) and crystallised from ether/petrol to give 2.04 g. product, m.p. 115-116 deg.C. |