| abstract |
Provided: a biological reaction device that reduces the burden and harm exerted on microorganisms, etc. in a biological reaction, and enables a biological reaction using microorganisms, etc., to be efficiently and economically performed becomes; and a biological reaction method using the biological reaction device. In order to reduce the burden and harm exerted on the microorganisms, etc., the amount per minute of a biological culture solution extracted from a culture tank and then returned to the culture tank after being mixed with micro-nano Is adjusted to at least 1% to less than 48% of the biological culture solution housed in the culture tank, and the attendant reduction in the dissolved oxygen concentration becomes by adjusting the oxygen partial pressure of a gaseous phase in the upper part the biological culture solution in the culture tank is compensated to at least 0.23 atm to less than 0.6 atm and / or adjusting the pressure of the gas phase in the upper part of the biological culture solution in the culture tank to at least 1.1 atm to less than 3.0 atm , |