http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-112017005025-T5
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6f39496e5bb60c8b92b4b854acc87af http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c38180f3599c802f35e66cd7a8aa1267 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-11 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-0281 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1858 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-983 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0634 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-14 |
| filingDate | 2017-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b15a1cafec7d33b9b7aa57265565069 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_516f3d2ac9b5224a1e8652d75ac6ee35 |
| publicationDate | 2020-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-112017005025-T5 |
| titleOfInvention | Compositions containing adjustable concentrations of growth factors from blood serum and clot hypoxia-conditioned medium and process for their preparation |
| abstract | The present invention is based on the idea of simulating a wound extracorporeally in order to obtain wound healing / regenerative growth factor mixtures. The invention provides a method of separating the growth factors released from cells after coagulation (coagulation-induced signal phase) from the growth factors secreted by cells under hypoxia (hypoxia-induced signal phase), followed by mixing the two phases at defined ratios to get a new composition. Peripheral blood is collected and coagulated or centrifuged to induce coagulation. The serum is completely or partially removed and replaced with fresh medium with a volume equal to or less than the volume of the serum removed. The clot is incubated in fresh medium at a temperature of 10 to 40 ° C under hypoxia (1 to 10% O 2 ) for 1 to 7 days. The clot-conditioned medium is then collected and mixed with the serum in a defined ratio to obtain the composition. Compositions comprising adjustable concentrations of growth factors derived from blood serum (coagulation-induced phase) and clot-conditioned medium (hypoxia-induced phase) can be added to suitable carriers and can be applied topically or injected into a subject to aid wound healing, skin regeneration or rejuvenation support. |
| priorityDate | 2016-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 162.