http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10349484-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eab56e4fe8837840887f41af83e328ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M29-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 |
| filingDate | 2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9035618b8f87bc2bd2106a2f8167157 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c46397dcf357da8793f9c778b09adb1 |
| publicationDate | 2005-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10349484-A1 |
| titleOfInvention | Method and bioreactor for culturing and stimulating three-dimensional, vital and mechanically resistant cell transplants |
| abstract | It is the object to provide a method and a bioreactor for the production of three-dimensional, vital and mechanically resistant cell cultures, which can be cultivated and stimulated in close temporal relation or simultaneously. The bioreactor should enable GMP-compliant graft cultivation under guaranteed sterile conditions. The bioreactor (1) consists of a base body which is pressure-tight and sterile connected to a reactor closure (21) and forms at least one reactor space in which a deposition surface for a graft (11) and a miniature actuator (14) are implemented. Furthermore, the bioreactor (1) is provided with at least two hose coupling connections (19) for the medium supply and medium discharge or for gassing. The invention enables a GMP-compliant production of three-dimensional, vital and mechanically resistant cell cultures, preferably cartilage cell constructs, which can be cultured and stimulated in a closed mini-bioreactor simultaneously, sequentially or after a time-controlled process. These so bred grafts are available as a tissue replacement material for the treatment of z. As connective and supporting tissue defects, direct articular trauma, rheumatism and degenerative joint diseases available and can be such. B. in knee osteoarthritis an alternative to the conventional (surgical) therapeutic approaches such. B. the ... |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007045619-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102010026369-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102008050424-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102008050424-B4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005049905-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022067369-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102018122745-B3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11000711-B2 |
| priorityDate | 2003-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.