http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10346228-B4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44df766f7fca9d1c4f11e8e597b09ef1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-05 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B59-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B59-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-34 |
| filingDate | 2003-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47034432824c781d7cc8785d6e5d70b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a1b768ecd9a4808e9688f964c4a76f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7eb86f4841e0b411066f7cb6e871a321 |
| publicationDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10346228-B4 |
| titleOfInvention | Preparation of [18 F] Fluorinated Aromatic L-Amino Acids |
| abstract | Process for the preparation of [ 18 F] fluorinated aromatic L-amino acids, comprising the following steps: (1) providing the L-enantiomeric compound shown below in a suitable reaction medium: wherein R 1 and R 2 are suitable protecting groups for OH groups, if a hydroxyamino acid is to be prepared; where Z is an electron-withdrawing group; wherein Y is a leaving group for nucleophilic substitution; wherein R 3 corresponds to one or more suitable protecting groups for an amino function; wherein R 4 corresponds to a suitable protecting group for a carboxyl function; (2) nucleophilic substitution of Y by a negatively charged [ 18 F] fluoride ion to prepare the compound shown below: (3) Cleavage of Z to produce the compound shown below: (4) hydrolytic cleavage of R 3 and R 4 for the preparation of the compound shown below: (5) hydrolytic cleavage of R 1 and R 2 for the preparation of the [ 18 F] fluorine-labeled aromatic L-amino acid shown below: wherein R 5 and R 6 are substituents each corresponding to an H atom or an OH group. |
| priorityDate | 2003-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.