| abstract |
The invention relates to 1,3,4-oxa- and 1,3,4-thiadiazol-2-yl (thio) phosphoric acid triamides of the general formula (I), processes for their preparation and their use as agents for regulating or inhibiting the enzymatic urea hydrolysis In formula (I): X, Y = independently of one another oxygen or sulfur R 1 , R 2 = independently of one another hydrogen, C 1 -C 8 alkyl / heteroalkyl, C 2 -C 8 alkenyl / heteroalkenyl, C 2 -C 8 alkynyl / heteroalkynyl, C 3 -C 8 cycloalkyl / heterocycloalkyl, C 3 -C 8 cycloalkenyl / heterocycloalkenyl, C 6 -C 10 aryl / heteroaryl, aralkyl, heteroarylalkyl, alkaryl, alkheteroaryl, alkoxy, aryloxy, hetaryloxy, alkylthio, arylthio, hetarylthio, acyl, aroyl, acyl, hetaroyl Hetaroyloxy, alkoxycarbonyl, aryloxycarbonyl, hetaryloxycarbonyl, amino, alkylamino, dialkylamino, alkylsulfonyl, arylsulfonyl, fluorine, chlorine, bromine, iodine, hydroxy, cyano, nitro, sulfo, carbonyl, carboxy, carbamoyl, sulfamoyl, where the radicals R 1 and / or R 2 can optionally be substituted independently and independently of one another with one or more of the above-mentioned groups. In addition, the invention comprises salts and metal complexes of compounds of the general formula (I) which have urease-inhibiting activity. The 1,3,4-oxa- and 1,3,4-thiadiazol-2-yl (thio) phosphoric acid triamides according to the invention are extremely effective urease inhibitors with good resistance to hydrolysis and can also be technically problem-free and ... |