| abstract |
Compounds of formula I. are suitable for the production of medicaments for the prophylaxis and therapy of diseases in the course of which an increased activity of matrix metalloproteinases are involved. These include diseases such as degenerative joint disease, for example osteoarthrosis, spondylosis, cartilage loss after joint trauma or prolonged immobilization of the joint after meniscus or patella injuries or torn ligaments, or a connective tissue disease such as collagenosis, periodontal diseases, wound healing disorders or a chronic musculoskeletal or inflammatory disease, such as inflammatory or inflammatory disorders, such as inflammatory or immune-related inflammatory disorders chronic arthritis, arthropathy, myalgia or disorders of the bone metabolism or an ulceration, atherosclerosis or stenosis or an inflammatory disease or cancer, tumor metastasis, cachexia, anorexia or septic shock. |