| abstract |
Depot microspheres of a huperzine A compound of the formula (Ia) and a water-insoluble, biodegradable pharmaceutically acceptable polymeric additive, in which X and Y, independently of one another, denote hydrogen or methyl and Z 1 and Z 2 , independently of one another, denote hydrogen or together the radical wherein the pharmaceutically acceptable polymeric additive is poly (D, L-lactide-co-glycolide) (PLGA), poly (glycolic acid), poly (3-hydroxybutyrate), polylactone, poly (acid anhydride), poly (hydroxybutyrate-hydroxyvalerate) Copolymer, poly (acrylicglucosan), poly (lactic acid) polyethylene glycol, poly (hydroxyacetic acid) polyethylene glycol or a mixture thereof. |