| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69c68a76c0f543aff42aff4f02b319c5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-38011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2002-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55e0bd586c4454c8427ea10a6a10f019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_221ef41d7a1a2dd95a586b07c97d5f43 |
| publicationDate |
2003-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-10235733-A1 |
| titleOfInvention |
RNA amplification system with components from the plant in animal cells |
| abstract |
The invention relates to a method and a novel system for constitutive or inducible, stable or transient intracellular amplification of foreign RNA in an animal cell or an organism. The system is based on an autonomous, RNA-dependent RNA amplification by expression of the RNA-dependent RNA polymerase (RdRP) of a plant virus in animal cells. The amplification is initiated by an RNA transcript (primary transcript) with the cis-active sequences for this RdRP. The amplified RNA can serve as mRNA for protein synthesis, as effector RNA (for example as anti-sense RNA against certain mRNA or viral RNA molecules, as a ribozyme against cellular RNA molecules or recombinant structural RNA in ribosomes or spliceosomes) or as genomic RNA for the production of recombinant viruses. Applications in vivo include gene therapy, vaccination and therapeutic vaccination. |
| priorityDate |
2001-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |