| abstract |
The present invention relates to the coupling of proteins to a modified polysaccharide derived from starch, wherein the binding interaction between the modified polysaccharide and the protein is based on a covalent bond, which is the result of a coupling reaction between the terminal aldehyde group or one from this aldehyde group by chemical reaction resulting functional group of the modified polysaccharide molecule and a functional group of the protein which is reactive with this aldehyde group or functional group of the polysaccharide molecule resulting therefrom, the bond resulting directly from the coupling reaction possibly being modified by a further reaction to form the covalent bond mentioned above. The invention further relates to pharmaceutical compositions comprising the conjugates formed in the coupling and the use of these conjugates and compositions for the prophylactic or therapeutic treatment of the human or animal body. |