| abstract |
The object of the present invention relates to a carbonic acid adduct (KA) comprising carbonic acid, at least one amine and optionally at least one salt preparable by a process comprising the steps a) providing a solution (A) comprising dissolved CO, optionally b) dissolving one Base (BA), which does not correspond to the amine (AM), in the solution (A) to obtain the solution (A1), c) dissolving the at least one amine (AM) in the solution (A) or (A1), under Obtaining the solution (B), d) freezing the solution obtained after completion of step c) and e) storing the solution frozen in step d) at - 100 to 0 ° C for not longer than 4 days. Wherein the content of COin of the solution subjected to the step c) is at least 6 g / l. Furthermore, the invention relates to a process for preparing the carbonic adduct (KA), a pharmaceutical preparation (PZ) comprising the carbonic adduct (KA), and processes for their preparation and the use of the carbonic adduct (KA) or the pharmaceutical preparation (PZ) in therapy for a number of indications. |