http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102014006224-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6c26464c48cf7a4a485d9793a9f347f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbab50e5e9915948d68b9fe56fcd0950 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-34 |
| filingDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d7c5e0bf06ec08029b2077fa48fb46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfa20900b56a368c381f8e5d909f08cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da930c7c120633d4d844baf75bd61fe9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a62ae076aebdd6555574c14887938d |
| publicationDate | 2015-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102014006224-A1 |
| titleOfInvention | Process for the preparation of 2-aryl-2-alkyl-malonic acids |
| abstract | The invention relates to a process for the preparation of 2-aryl-2-alkyl-malonic acids of the formula in which RX with R is hydrogen (H-), methyl, ethyl, propyl, n-isopropyl or butyl radical, and X is the same fluorine, chlorine, nitro, methoxy and ethoxy radical at any position of R, and Y-aryl with Aryl is phenyl, naphthyl, biphenyl or benzoylphenyl radical, and Y is hydrogen (H-), fluorine, chlorine, nitro, methoxy, ethoxy, as well as methyl, ethyl, propyl, n-isopropyl or butyl radical from corresponding 2-aryl-alkanoic acids which satisfy the following formula: where X, alkyl, Y and aryl have the same meaning, and do not change before and after reaction, as an intermediate for the preparation of optically pure 2-aryl-alkanoic acids from the racemates or non-enantiomerically pure 2-aryl-alkanoic acids. The invention is characterized by esterifying the carboxylic acid residue to a benzyl ester, converting the benzyl ester into a malonyl malonate by addition of benzyl chloroformate in the presence of a strong base to deprotonate the chiral C atom, hydrogenating the malonic acid dibenzyl ester to the free acid. |
| priorityDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.