| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4fd9e7c05c1c4c32ee984b3a74cae786 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16134
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-16134
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55555
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-55516
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-627 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-245
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2011-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5d51cf9a4e7a6c3c847efa30a3351f7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8277eda04963e6255f2bde46ca3df9eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6794038b90428ae047eed111a21b5985
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_227b923137aab03710d74304f0c98751
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf9c0b9d95a9e40720b4b40a92e7c8f5 |
| publicationDate |
2012-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-102011018499-A1 |
| titleOfInvention |
Topical nanoparticle vaccine for the immune stimulation of dendritic cells in the skin |
| abstract |
The invention relates to novel topical vaccines which specifically target the dendritic cells of the skin with the aid of a particle-based carrier system and thus induce effective prophylactic and / or therapeutic T-cell-mediated immunity. The invention further relates to the composition of such a vaccine of antigenic determinants for cytotoxic effector T cells and helper T cells, and to the use of synthetic analogs of bacterial lipopeptides as TLR-based adjuvants for enhancing the specific immune response. A combination of the vaccine components is immobilized on nanoscale carrier particles, transported to the skin by these in an active transport process in the hair follicles and temporarily deposited there. The active ingredients released under the physiological conditions in the hair follicle diffuse to the target structures in the skin, stimulate the cell surface receptors of the dendritic cells and induce a targeted T cell immune response. The new topical nanoparticle vaccines and their formulations are suitable on the one hand for the prevention and on the other hand for the treatment of diseases such as infections, cancer, autoimmune diseases, chronic inflammations and allergies in humans and animals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021229014-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021229015-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021229020-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102016005550-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3909612-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3909613-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3909614-A1 |
| priorityDate |
2011-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |