http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102010027827-B3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fab5a78161702097f97524ce6e5cdcd7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2010-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2f55e755c2d02fa824f896f6df26c57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf17df91b48e5c24f78e0ce7da4a10e0 |
| publicationDate | 2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102010027827-B3 |
| titleOfInvention | Method and means for identifying substances that inhibit IgE production |
| abstract | The invention relates to the field of biomedical and pharmacological research, in particular in the field of immunology, allergies and autoimmune diseases. The inventors have demonstrated that SWAP-70 is a major regulator of STAT-6 and BCl-6 specific for IgE production in B cells by enhancing the effect of STAT-6 and the effect of BCL -6 antagonized. The inventors have observed no influence of SWAP-70 on the expression of other genes, which are also regulated by STAT-6 and / or BCL-6. In summary, it can be concluded that SWAP-70 positively regulates IgE production by shifting the interaction of the two antagonists STAT-6 and BCL-6 with regulatory elements of the IgE gene in favor of the activator STAT-6. Based on these findings, the invention provides a screening method which allows to identify new drugs which specifically inhibit IgE production. The substances identified by the method according to the invention are particularly suitable for the treatment of IgE-mediated allergies and IgE-dependent autoimmune diseases. |
| priorityDate | 2010-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 245.