http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102010004452-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf920ea3ab8a199aef9a8dd334b2713b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J31-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J53-008 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J53-00 |
| filingDate | 2010-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8699c53eebea6a88afbb5f43ef701cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c52c7095b97cf7a389902a5df8cc4df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_57e675aec5161508c7d6e3c1d10e0305 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1523e71b88dc4ce0e3b863663d1045b9 |
| publicationDate | 2011-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102010004452-A1 |
| titleOfInvention | Process for the preparation of drospirenone from dehydroepiandrosterone |
| abstract | The invention relates to a process for the preparation of drospirenone starting from 15,16-methylenprasterone by reaction with a strong base and subsequent reaction of the reaction product of lithium or butyllithium and 1-bromopropyl-3-trimethylsilyl ether to 15,16-methylene-17β-hydroxy 17α- (propyl-3-trimethylsilyloxy) -prasterone, cleavage of the trimethylsilyl protecting group and oxidative ring closure to 15,16-methylene-17 (S) -spirolactone-androst-4-en-3-one (MADO-lactone); Enolization to 3-methoxy-15,16-methylenandrost-4,6-dien-3-one-17 (S) -spirolactone, subsequent oxidation to 15,16-methylenandrost-4,6-dien-3-one-17 ( S) -spirolactone (MDD-lactone) and methylenation to drospirenone. Furthermore, the invention relates to a synthesis route from Prasteron drospirenone on the above reaction sequence. |
| priorityDate | 2010-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.