abstract |
Microfluidic devices and methods are provided for analyzing the glycan profiles of glycoproteins. Some embodiments of the microfluidic devices include a deglycosylation column for cleaving off the glycans, optionally a purification column for removing the proteins, a trap column for accumulating the glycans and a separation column for separating the glycans. The microfluidic devices and methods significantly improve the rate and resolution of glycan analysis. |