http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102008011868-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4e0fcf309b0d49f890b63cfe2018d4a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-29 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-29 |
| filingDate | 2008-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da16ec91d40899119c527d2ad0146f87 |
| publicationDate | 2009-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102008011868-A1 |
| titleOfInvention | Agent for the treatment of bone resorption |
| abstract | The invention relates to an agent for the treatment of bone resorptions, which consists of specific for osteoclasts (bone-dissolving cells) carbonic anhydrase inhibitors and / or ATPase inhibitors in combination with parathyroid hormone. Areas of application are medicine and the pharmaceutical industry. Bones are subject to permanent remodeling, which is a prerequisite for adaptation to changed load, repair processes and for the function of the bone as calcium storage. In healthy bone, cultivation by osteoblasts and degradation by osteoclasts are coupled and finely regulated. This balance is disturbed in bone disorders. If the degradation predominates, the bone loses its strength, micro-fractures develop in the cancellous bone - a typical example of this is the (slow) collapse of vertebral bodies - or fractures occur under load. Other examples include fractures of the femoral neck, forearm and carpal bones. In the Federal Republic of Germany live 3 million people with vertebral fractures, 70000 femoral neck fractures are observed annually. The consequential costs of femoral neck fractures are enormous. Depending on their etiology, a distinction is made between various diseases that are associated with a reduction in bone mass. Most significant are postmenopausal osteoporosis of women and, increasingly, senile osteoporosis, which affects both sexes ... |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013261077-A1 |
| priorityDate | 2008-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 65.