| abstract |
The invention relates to 15,16-methylene-17- (1'-propenyl) -17-3'-oxidoestra-4-en-3-one derivatives having the general chemical formula I, wherein the Z, R 4 , R 6a , R 6b , R 7 and R 18 have the meanings given in claim 1, and their solvates, hydrates and salts, including all crystal modifications and all stereoisomers of these compounds. The invention further relates to the use of these derivatives for the manufacture of a medicament for oral contraception and for the treatment of pre-, peri- and post-menopausal complaints as well as medicaments containing such derivatives, in particular application in the aforementioned indications. The derivatives of the invention have a gestagenic and in addition, in addition, an antimineralcorticoidal and neutral to mildly androgenic action. |