| abstract |
The 17β-cyano-19-nor-androst-4-ene derivatives of the present invention have gestagenic activity. They have the general chemical formula 1 in which Z is selected from the group comprising O, two hydrogen atoms, NOR and NNHSO 2 R, wherein R is hydrogen or C 1 -C 4 alkyl, R 4 is hydrogen or halogen, further either: R 6a , R 6b together form methylene or 1,2-ethanediyl or R 6a is hydrogen and R 6b is selected from the group comprising hydrogen, methyl and hydroxymethylene, and R 7 is selected from the group comprising hydrogen, C C 1 -C 4 -alkyl, C 2 -C 3 -alkenyl and cyclopropyl, or: R 6a is hydrogen and R 6b and R 7 together form methylene or omitted to form a double bond between C 6 and C 7 , R 9 , R 10 is hydrogen or are eliminated to form a double bond between C 9 and C 10, R 15, R 16 are hydrogen or together form methylene, R 17 is selected from the group comprising hydrogen, C 1 -C 4 alkyl and allyl, wherein at least one the substituents R 4 , R 6a , R 6b , R 7 , R 15 , R 16 and R 17 is hydrogen or R 6b and R 7 is omitted to form a double bond between C 6 and C 7 , and also include their solvates, hydrates, stereoisomers, diastereomers, enantiomers and salts. |