| abstract |
ThenThe invention relates to a non-specific modification methodnacting inhibitors of 11 beta-hydroxysteroid dehydrogenase (11nbeta-HSD) with pentacyclic skeleton of the Oleanan and Ursan type,nwhich makes it possiblento produce chemical compounds that are essentially specificnthe isoform of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSDn1) inhibit and thereby substantially no inhibitory activity against thenIsoform of 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSDn2). Furthermore, the invention relates to new chemicalnCompounds with Nor-Oleanan- or Nor Nor-Ursan skeleton. ThesenInhibitors act as substantially specific inhibitors ofn11 beta-HSD 1 and are thus about for treatment and preventionnsuch as diabetes, metabolic syndrome, obesity, hyperlipoproteinemias, hyperglycemia, hyperinsulinemia, arteriosclerosis,nDementia, depression, osteoporesis, glaucoma or viral diseasesnsuitable. |