http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102006042516-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac1460c08de279f2ddc7f78ec7fdda79 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-06 |
| filingDate | 2006-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6969e878920af42ebf86e192fb100df6 |
| publicationDate | 2007-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102006042516-A1 |
| titleOfInvention | Reducing a risk for allerg. and hypersensitivity reactions in the event of application of the medicinal product Tobramycin solution for injection or infusion due to a sodium metabisulfite-free dosage form |
| abstract | Technical field of the invention: Pharmaceutical production of tobramycin-containing injection solutions. Description of the invention: To date, tobramycin-containing injectable solutions have always included sodium metabisulfite as an antioxidant. In the case of sodium metabisulphite-containing medicaments with the active ingredient tobramycin, however, parenteral administration, especially in asthmatics, can lead to allergic and hypersensitivity reactions, which may manifest as vomiting, diarrhea, wheezing, acute asthma attack, disturbance of consciousness or shock. These reactions can be individually very different and also lead to life-threatening conditions. Under the direction of medphano Arzneimittel GmbH, a sodium metabisulfite-free application form was developed, which now contains sodium chloride, sulfuric acid, sodium hydroxide and water for injections in addition to the active ingredient and di-sodium edetate-2-water as further constituents. Advantages of the invention: Advantages of this sodium metabisulfite-free dosage form of a tobramycin solution for injection lie in the lower risk of allergic and hypersensitivity reaction icons as well as in the practical handling of the drug substance tobramycin. Furthermore, there is a new application, since sodium metabisulfite-free tobramycin injection solution can be administered undiluted slowly directly into a vein, while for Natriummetabisulfit-containing ... |
| priorityDate | 2006-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.