http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102006032427-A1

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filingDate 2006-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_949c513352f4ef09fb821f1edb3173f9
publicationDate 2008-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber DE-102006032427-A1
titleOfInvention Use of compositions of clozapine, quetiapine, hard or very poorly soluble acid addition salts of quetiapine and / or olanzapine for the preparation of solutions for oral administration
abstract The invention relates to the use of compositions with a) 10 to 200 mg / ml clozapine, 25 to 300 mg / ml quetiapine, 25 to 300 mg / ml (expressed as quetiapine base) of one or more difficultly or very slightly soluble acid addition salts of quetiapine and / or 1 to 20 mg / ml olanzapine as active substance (s), b) 0 to 20 mg / ml benzyl alcohol and / or phenylethyl alcohol, c) o to 200 mg / ml of propylene glycol, (d) from 0 to 50 mg / ml of one or more essential oils, flavorings and / or sweeteners and e) balance of 1 ml each of one or more liquid polyethylene glycol (s), poly [oxypropylene (s)], poloxamer (s), vegetable oil (s), medium chain triglycerides, polyoxyethylated (s) and polyoxypropylated fatty acid glycerides (s), low-viscosity / low-viscosity paraffin (s) and / or glycerol, wherein instead of c) or in addition to c) up to 50 mg / ml of ethanol and / or up to 0.5 wt .-%, based on the / the active ingredient (s), of one or more C 3-4 alkanol (s), for the preparation of solutions for oral administration, characterized in that the content of e) of peroxides <100 ppm and the content of the solution of residual oxygen <1 mg / ml. By the invention well drippable stable solutions are obtained.
priorityDate 2006-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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