| abstract |
ThenThe present invention relates to peptides having a modulatorynEffect on proteasomal activity in vitro and in vivo. ThenPeptides have an amino acid sequence motifnfrom a human protein, preferably human telomerase reversesnTranscriptase, on. Furthermore, the invention is based on compositionsndirected, which contain the peptides of the invention, onnPolynucleotides and vectors, which for the peptides of the inventionnand to cells containing the peptides of the invention,nContain polynucleotides or vectors. Finally, the invention relates tonUse of peptides, polynucleotides and vectors as well as methodsnfor the modulation of proteasomal activity in vitro and in vivo. |