| abstract |
The present patent application relates to 11β-benzaldoxime derivatives of D-homoestra-4,9-dien-3-ones of the formula I, wherein R 1 is a hydrogen atom, a C 1 -C 6 -alkyl, C 1 -C 6 -acyl, C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylthiocarbonyl, C 1 -C 6 -alkylaminocarbonyl, arylaminocarbonyl; R 2 is a hydrogen atom, a C 1 -C 6 alkyl or C 1 -C 6 acyl group; Compounds of formula I bind more strongly to the glucocorticoid receptor than to the progesterone receptor and are effective antiglucocorticoids. According to the invention, they are suitable for the treatment and / or prevention of symptoms and / or diseases attributable to an androgen deficiency induced by glucocorticoids, in particular cortisol. |