http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005047717-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eab56e4fe8837840887f41af83e328ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-22 |
| filingDate | 2005-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6382b08459b12ce7e7353fe0058867e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34dc7bb038427c39cd465fd82d65449f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5ef7f4980ab71f87833e382a4847383 |
| publicationDate | 2007-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102005047717-A1 |
| titleOfInvention | Ribonucleases with adenosine specificity |
| abstract | ThenThis invention relates to ribonucleases having a substrate specificity for adenosine,ncomprising an amino acid sequence,nat the amino acid,nthe asparagine 43 corresponds to the ribonuclease T1 from Aspergillus oryzae,nis substituted by tyrosine and / or the amino acid, thenAsparagine 44 corresponds to ribonuclease T1 from Aspergillus oryzae,nis substituted by lysine or histidine and / or the amino acid, thenTyrosine 45 corresponds to the ribonuclease T1 from Aspergillus oryzae,nis substituted by serine or tyrosine and / or the amino acid, glutamaten46 corresponds to the ribonuclease T1 from Aspergillus oryzae, bynLysine is substituted and / or the amino acid, the aspartate 49 of the ribonucleasenT1 from Aspergillus oryzae corresponds to valine or histidinenis substituted and / or the amino acid, the serine 53 of the ribonuclease T1nfrom Aspergillus oryzae, substituted by threonine.nAlso part of the invention are nucleic acids whichnfor thenencode ribonucleases according to the inventionnand methods for producing the ribonucleases of the invention.nThe ribonucleases according to the inventionnsplit single-strandednRNA highly specific for adenosine residues. Field of application is thenUse of the ribonucleases according to the inventionnin the cleavage of RNA, in RNA sequencing, the determinationnof unpaired adenosine residues in RNA secondary structures and in methodsnfor the investigation of SNPs (single nucleotide polymorphism). |
| priorityDate | 2005-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.