| abstract |
The present invention provides a cell-free graft comprising (i) a contiguous, open-porosity framework-forming matrix of a biologically and pharmaceutically acceptable material and (ii) serum. According to a particularly preferred embodiment, the matrix additionally contains a gel. In a second aspect, there is provided a method of making such a cell-free graft by contacting the matrix and gel, if any, with the serum. Optionally, the graft may be dried with serum. Alternatively, the matrix and gel, if present, may be in the dried state prior to contacting the serum. Finally, in a third aspect, the present invention provides the use of the cell-free graft for tissue regeneration, and in particular for the regeneration of cartilage and / or bone. |