http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005028937-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a51c718ef328e86ce2a410b4c67847ee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-80 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-352 |
| filingDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_703dac41eb8af7ee1f7279a8f2ed9f0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_836248ef9d9441bd01c5ff5779454ba7 |
| publicationDate | 2007-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102005028937-A1 |
| titleOfInvention | Process for the preparation of dronabinol |
| abstract | The present invention relates to a process for the preparation of dronabinol ((6aR-trans) -6a, 7,8,10a-tetrahydro-6,6,9- trimethyl-3-pentyl-6H-dibenzo [b, d] pyran-1-ol, Δ 9 -tetrahydrocannabinol (Δ 9 -THC)) from cannabinol (CBD) by cyclization of cannabidiol (CBD) (2- [1R-3 -Methyl 6- (1-methylethenyl) -2-cyclohexen-1-yl] -5-pentyl-1,3-benzenediol) to Δ 9 -THC. The inventive method is characterized in that cannabidiol (CBD) is initially charged in an organic solvent and cyclized in the presence of a molecular sieve with heating to Δ 9 -THC. It has been found that in the inventive method, the molecular sieve, in addition to the previously described drying properties, also has strong catalytic properties, which are at the forefront of this conversion. Cyclizations, which are carried out only in the presence of a Lewis acid catalyst, are generally much slower and give poorer yield of Δ 9 -THC than cyclizations carried out in the presence of a molecular sieve. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016135346-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11413268-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10568863-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3061510-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3978095-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8324408-B2 |
| priorityDate | 2005-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.