http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005026081-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c0c953846486e2013064e1d0759ff6f0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-924 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2005-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8ff8b11efae0713d4a473ecf2fe20cc |
| publicationDate | 2006-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102005026081-A1 |
| titleOfInvention | Enrichment, isolation and screening of immunologically active glycans and proteoglycans from fungi |
| abstract | The present invention encompasses methods for enrichment, isolation and screening of immunologically active macromolecules from natural sources (eg medicinal mushrooms, so-called medicinal mushrooms). Cell wall-bound polysaccharides (glycans, PS) and proteoglycans (PG) are released enzymatically from chitin-containing organisms to avoid unphysiological extraction conditions. This is done in a gentle way as part of a co-fermentation of the organisms to be disrupted with vital biocatalysts (eg brewer's yeast, Saccaromyces cerevisiae). The recovery of immunologically active PS and PG from the substance mixture takes place by affinity chromatography on embedded, immobilized immune cells. This method allows testing of immunological activity during the separation process. To demonstrate interactions between immunoactive PS / PG and immune cells (eg, macrophages, T lymphocytes, B lymphocytes), the PS and PG are fluorescently labeled by chemical or enzymatic reactions. The enzyme-catalyzed fluorescence labeling involves UDP-glucose and specific glycosyltransferases. The entire process serves the development of a product range of numerous natural substances with immunoactive properties, the z. B. in the context of an individual cancer therapy can be used. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102015219540-A1 |
| priorityDate | 2005-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 110.