| abstract |
The present invention describes the novel 18-methyl-19-nor-17-pregn-4-ene-21,17-carbolactones of general formula I, wherein Z is an oxygen atom, two hydrogen atoms, a grouping = NOR or = NNHSO 2 R, where R is a hydrogen atom or a straight-chain or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R 4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, R 6 and / or R 7 may be α- or β-positionally and R 6 and R 7 are independently a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or together a methylene group or a double bond mean. The novel compounds have gestagen and antimeralcorticoid activity and are suitable for the preparation of pharmaceutical preparations, for example for oral contraception and the treatment of pre-, peri- and postmenopausal complaints. |