http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10163333-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cff856e19e4e21f122a3c9accf248d8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43536 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
| filingDate | 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f82fce0a35c82fb8bc33cc4619169ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_713af2c8a815328173b2795c4c34e0b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5ca146a0abacd57f7344a77757dab33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1654a03e415c700d63055b2505fbdffb |
| publicationDate | 2003-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10163333-A1 |
| titleOfInvention | Modified tridegins, their production and use as transglutaminase inhibitors |
| abstract | The present invention relates to modified tridegins, polypeptides derived from SEQ ID No. 1, the modification being that at least one cysteine residue and / or one of the following amino acids - Lys2, Lys7, His10, Gly12, Leu24, Tyr31, Phe34, Arg39, Ile45, Met48, Asp50, Pro55, Phe58, Asn60, Pro65 - is substituted by another amino acid, and / or the N- and C-terminus are delegated, the remaining polypeptide containing at least the amino acid sequence DDIYQRPVEFPNLPLK (SEQ ID No. 47), and / or being covalently linked to polyethylene glycol. The polypeptides according to the invention are new inhibitors of transglutaminases, in particular factor XIIIa, the terminal enzyme of the blood coagulation cascade. The present invention also relates to methods for producing these inhibitors and to their use as transglutaminase inhibitors. |
| priorityDate | 2001-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.