http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10141443-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14ca7f0f16e9309dedfe101008643f6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b96abc7765fc1d1a20b6f912e381cc4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y103-99005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2001-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a277022c6f6a6866bb51d8e0137739ec |
| publicationDate | 2003-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10141443-A1 |
| titleOfInvention | Use of molecular-biologically produced, non-viral active ingredients for the treatment of acne |
| abstract | The use of at least one molecular-biologically produced, non-viral active substance (antisense oligonucleotides, ribozymes, stabilized ribozymes, aptamers, mirror naptamers, chimeric RNA / DNA oligonucleotides, naked plasmid DNA, liposomally encapsulated DNA), in particular antisense oligonucleotide Specificity for a nucleic acid target sequence of the genes which codes for the steroid hormone receptors and / or the steroid hormone metabolizing enzymes, in particular for the androgen receptor and / or the 5alpha reductase, for the treatment of acne and acne-like dermatoses, including rosacea, is described , For this purpose, special antisense oligonucleotides and degenerate sequences are preferably selected from these and are preferably introduced into the target cells, in particular human sebocytes and / or keratinocytes, by means of a liposome-mediated transfection. In these target cells, a specific inhibition of androgen-induced, specifically testosterone-induced, stimulation of sebocyte or keratinocyte proliferation was determined and evaluated by the described antisense oligonucleotides. The effects according to the invention were demonstrated, for example, using the sebocyte cell line SZ95 and primary keratinocytes of the skin. |
| priorityDate | 2001-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.