| abstract |
The present invention relates to novel imidazolidine derivatives of the formula I in which B, E, W, Y, R, R 2, R 3, R 30, e and h have the meanings given in the claims. The compounds of the formula I are valuable active pharmaceutical ingredients which are suitable, for example, for the treatment of inflammatory diseases, for example rheumatoid arthritis, or of allergic diseases. The compounds of the formula I are inhibitors of the adhesion and migration of leucocytes and / or antagonists of the group of integrins belonging adhesion receptor VLA-4. They are generally useful in the treatment of diseases caused by or associated with an undesirable level of leukocyte adhesion and / or leukocyte migration, or in which cell-cell or cell-matrix interactions involving VLA-4 interactions are involved Receptors are based with their ligands. The invention further relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical preparations which contain compounds of the formula I. |