http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10136434-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bb66d9373d09efad73c142762f6dfb00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-192 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-26 |
| filingDate | 2001-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_761c4fa13e1391abf6a4cf91bf9384a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8415dcb4c4b4ad32cbfb4ea0fca6d04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73c03e52c6bb6407394c003189c8c051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53f6ef063494004ccdb562581cff438e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53e20442b50d750ed8db0d167ec6ab54 |
| publicationDate | 2003-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10136434-A1 |
| titleOfInvention | Carboxamides, their preparation and their use as medicines |
| abstract | The present invention relates to antithrombotic compounds of the general formula DOLLAR F1 in which R¶1¶ to R¶4¶, R¶8¶, R¶9¶ and Ar are as defined in claim 1, and the compound 2- (5-carbamimidoyl -2-hydroxy-phenyl) -N- [3-chloro-4- (pyrrolidin-1-yl- DOLLAR A carbonyl) phenyl] acetamide, their tautomers, their stereoisomers, their mixtures, their prodrugs and their salts, which have valuable properties. DOLLAR A The compounds of the general formula I above, in which Ar represents a phenyl or naphthyl group substituted by the radicals R¶5¶, R¶6¶ and R¶7¶ and R¶5¶ represents a cyano group, are valuable intermediates for the preparation the corresponding compounds of the general formula I in which R¶5¶ represents an amidino group which is optionally substituted by one or two C¶1-3¶ alkyl groups. The compounds of the general formula I above, with the exception of those compounds in which Ar represents a phenyl or naphthyl group substituted by the radicals R¶5¶, R¶6¶ and R¶7¶ and R¶5¶ represents a cyano group, have valuable pharmacological groups Properties, in particular an antithrombotic effect and a factor Xa-inhibiting effect. |
| priorityDate | 2001-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 430.