| abstract |
The invention relates to methods for analyzing modifications of proteins with ubiquitin-related proteins and demodifications of proteins linked to ubiquitin-related proteins. Furthermore, the invention relates to methods for determining substances which influence these modifications or demodifications, and methods for detecting a defect in these modifications or demodifications. Finally, the invention relates to a method for identifying target proteins for modification with ubiquitin-related proteins as well as methods for producing a pharmaceutical composition. Furthermore, the invention relates to a kit, a fusion protein, a cell and an isopeptidase substrate and their uses in the analysis and / or diagnosis of ubiquitin-related modifications or demodifications of proteins. |