http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-10105866-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec5b8c0fc1f827c1360a8f5ea5652225 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-40 |
| filingDate | 2001-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2002-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-10105866-A1 |
| titleOfInvention | Process for the production of optically active, propargylic, terminal epoxides |
| abstract | The invention relates to a method for the enantioselective preparation of optically active, propargylic, terminal epoxides. According to the invention, in the first step of the process, compounds of formula 1 with an alcohol dehydrogenase, which preferably originates from horse liver or thermophilic microorganisms (such as, for example, Thermoanaerobium brockii or Thermoanaerobacter ethanolicus) or from Lactobacillus and is recombinantly overexpressed in Escherichia coli, in the presence of NAD (P) H implemented. In this reaction, the oxo group is reduced enantioselectively. Since both (S) and (R) -selective oxidoreductases can be used, the synthesis of both enantiomers is possible. Both enantiomers can be prepared using the same enzyme with the alcohol dehydrogenase from Lactobacillus brevis, since these compounds with R · 1 · = H and compounds with R · 1 · NOTEQUAL H convert to alcohols with the opposite configuration. In the second step of the process, the alpha-halogenated alcohol is converted into the enantiomerically pure epoxide using a base. DOLLAR F1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005028312-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102005028312-B4 |
| priorityDate | 2001-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 341.