| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9911f3ffb183144488431472d9039dfa |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1081
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate |
2001-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58bfe4117547c908769752e21ab235de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_060467f8251d7a23911907d926d49edf |
| publicationDate |
2002-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
DE-10103695-A1 |
| titleOfInvention |
Use of sialyltransferases for the diagnosis and therapy of tumor diseases |
| abstract |
The invention relates to the use of sialyltransferases, in particular the sialyltransferase ST6Ga1NAc-II for the diagnosis and therapy of tumor diseases. The mRNA expression of the enzyme sialyltransferase ST6Ga1NAc-II is increased in cases where lymph node metastases occur. Studies on 40 well documented cases of colorectal cancer show that ST6Ga1NAc-II expression is a prognostic factor in the consideration of such patients. In addition, by blocking the expression of the sialyltransferase ST6Ga1NAc-II, the synthesis of the tumor-associated antigen TF can be blocked, which may improve the prognosis. The invention also relates to inhibiting the expression of the enzyme by pharmaceutical agents. |
| priorityDate |
2001-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |