| abstract |
The present invention relates to acylaminoalkyl-substituted benzenesulfonamide derivatives of the formula I, DOLLAR F1 in which A, R (1), R (2), X, Y and Z have the meanings given in the claims. The compounds of the formula I are valuable active pharmaceutical ingredients which, for example, have an inhibiting effect on ATP-sensitive potassium channels on the cardiac muscle and / or on the vagal heart nerve and are suitable, for example, for the treatment of disorders of the cardiovascular system such as coronary heart disease, arrhythmias, cardiac insufficiency, Cardiomyopathy, decreased contractility of the heart or vagal dysfunction of the heart, or for the prevention of sudden cardiac death. The invention further relates to processes for the preparation of the compounds of formula I, their use and pharmaceutical compositions containing them. |