| abstract |
Compounds of formula 1 BQX¶1¶, in which B is a bioactive, cell adhesion-promoting molecule, Q is missing or an organic spacer molecule and X¶1¶ is an anchor molecule, selected from the group -Lys- (CO-CH¶2¶- (CH ¶2¶) ¶n¶-PO¶3¶H¶2¶) ¶2¶ (i), -Lys- [Lys- (CO-CH¶2¶- (CH¶2¶) ¶n¶-PO¶ 3¶H¶2¶) ¶2¶] ¶2¶ (ii) or -Lys- (Lys [-Lys- (CO-CH¶2¶- (CH¶2¶) ¶n¶-PO¶3¶H ¶2¶) ¶2¶] ¶2¶ (iii), and n is each independently 0, 1, 2 or 3, where a free amino group B group with a free carboxyl group of the spacer molecule Q or the anchor molecule X ¶1¶ or a free amino group of the radical Q with a free carboxyl group of the radical X¶1¶, linked to one another in peptides, and their salts, can be used as integrin inhibitors for the treatment of diseases, defects, inflammations and osteolytic diseases caused by implants such as osteoporosis, thrombosis, heart attack and arteriosclerosis, as well as for acceleration and Ve Reinforcement of the integration process of the implant or the biocompatible surface into the tissue can be used. |